9T5O image
Deposition Date 2025-11-05
Release Date 2026-09-02
Last Version Date 2026-09-02
Entry Detail
PDB ID:
9T5O
Keywords:
MEMBRANE PROTEIN
Title:
Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1, Conformation 2
Biological Source:
Source Organism(s):
Mus musculus (Taxon ID: 10090)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Homo sapiens, Escherichia coli mc1061
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.16 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9T5O validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Volume-regulated anion channe
Chain IDs:A, B, C, D
Chain Length:818
Number of Molecules:4
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:Volume-regulated anion channe
Chain IDs:I (auth: E), J (auth: F)
Chain Length:924
Number of Molecules:2
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:Synthetic Nanobody Sb1
Chain IDs:E (auth: G), F (auth: H), G (auth: I), H (auth: J)
Chain Length:118
Number of Molecules:4
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions
To Be Published ? ? ? (?)
Primary Citation of related structures
9T5O
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