ISDA: 9T3R

Deposition Date 2025-10-29

Release Date 2026-03-11

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9T3R

Keywords:

ANTITUMOR PROTEIN

Title:

Structure of human HER2 in complex with EPS232 Fab

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Receptor tyrosine-protein kin
Gene (Uniprot):ERBB2
Chain IDs:C (auth: A)
Chain Length:636
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P04626 Pfam ID:PF01030, PF00757, PF14843 EC:2.7.10.1

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:EPS232 Fab HC
Chain IDs:B (auth: H)
Chain Length:267
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:9T3R

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ig-like domain-containing pro
Chain IDs:A (auth: L)
Chain Length:216
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:9T3R

Ligand Molecules

Primary Citation

Elucidating the relationship between affinity and potency in the performance of therapeutic IgE.

Marano, F, McKenzie, C, Birtley, J.R, Hussain, S.A, Macleod, O, Goodacre, A, Wu, S, Amin, O.E, Faulkner, N, Devlin, J, Regan, L, Soni, K, Johnson, R.M, Pye, V.E, Wilson, T, Hardaker, E, FitzGerald, K.Show

Sci Rep 16 ? ? (2026)

PMID: 41912649 DOI: 10.1038/s41598-026-43772-6

Primary Citation of related structures

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