ISDA: 9T20

Deposition Date 2025-10-22

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9T20

Keywords:

TRANSFERASE

Title:

JAK2-ruxolitinib complex with Y1007F and Y1008F mutations in the activation loop

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.28

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase JAK2
Gene (Uniprot):JAK2
Mutagens:Y1007F, Y1008F
Chain IDs:A
Chain Length:316
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O60674 Pfam ID:PF07714 EC:2.7.10.2

Ligand Molecules

RXT

Primary Citation

Janus kinase 2 activation loop as a regulator of catalysis and trans-activation.

Miao, Y, Mykuliak, V.V, Hubbard, S.R, Silvennoinen, O, Hytonen, V, Haikarainen, T.Show

Int.J.Biol.Macromol. 374 153276 153276 (2026)

PMID: 42409141 DOI: 10.1016/j.ijbiomac.2026.153276

Primary Citation of related structures

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