ISDA: 9T1X

Deposition Date 2025-10-22

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9T1X

Keywords:

HYDROLASE

Title:

Plasmodium falciparum Aminopeptidase P in complex with hydroxamic-peptide based inhibitor 6d

Biological Source:

Source Organism(s):

Plasmodium falciparum 3D7 (Taxon ID: 36329)
synthetic construct (Taxon ID: 32630 )

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.55 Å

R-Value Free:

0.24

R-Value Work:

0.22

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Aminopeptidase P
Gene (Uniprot):APP
Chain IDs:A (auth: B), B (auth: A)
Chain Length:0
Number of Molecules:2
Biological Source:Plasmodium falciparum 3D7

UniProt ID:A0A144A2H0 Pfam ID:PF01321, PF16189, PF00557, PF16188 EC:3.4.11.9

Polymer Type:polypeptide(L)
Molecule:hydroxamic-peptide based inhi
Chain IDs:C, D (auth: E)
Chain Length:0
Number of Molecules:2
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P.

Mills, B.J, Gregory, K.S, Cozier, G.E, Taweechai, S, Loughlan, E, McConkey, G.A, Isaac, R.E, Foster, R, Acharya, K.R.Show

J.Biol.Chem. 302 111372 111372 (2026)

PMID: 41850401 DOI: 10.1016/j.jbc.2026.111372

Primary Citation of related structures

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