ISDA: 9T0W

Deposition Date 2025-10-20

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9T0W

Keywords:

TRANSFERASE

Title:

Crystal structure of the Mycobacterium tuberculosis histidinol-phosphate aminotransferase HisC in complex with the adduct PLP-BVL3572S

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis H37Rv (Taxon ID: 83332)

Expression System(s):

Escherichia coli bw25113

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.74 Å

R-Value Free:

0.23

R-Value Work:

0.19

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Histidinol-phosphate aminotra
Chain IDs:A, B
Chain Length:393
Number of Molecules:2
Biological Source:Mycobacterium tuberculosis H37Rv

Ligand Molecules

A1JSV

GOL

PEG

Primary Citation

BVL3572S inhibits HisC and AlaA, exploiting vitamin B6 dependency to kill Mycobacterium tuberculosis.

Edoo, Z, Lenne-Delmotte, A, Grosse, C, Devaere, M, Michel, M, Caron, G, Anoz-Carbonell, E, Djaout, K, Frita, R, Gaudin, C, Hofmann, L, Lecher, S, Megalizzi, V, Michelotti, A, Rengel, D, Rouan, P, Slupek, S, Tawk, L, Antoine, R, Kulyk, H, Dale, G, Guilhot, C, Willand, N, Lippens, G, Wintjens, R, Baulard, A.R.Show

Cell Chem Biol ? ? ? (2026)

PMID: 42580344 DOI: 10.1016/j.chembiol.2026.07.008

Primary Citation of related structures

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