ISDA: 9SZQ

Deposition Date 2025-10-15

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9SZQ

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of the E336K mutant of human Apoptosis Inducing Factor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Apoptosis-inducing factor 1,
Gene (Uniprot):AIFM1
Chain IDs:A
Chain Length:535
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O95831 Pfam ID:PF00070, PF14721 EC:7.1.1.2

Ligand Molecules

FAD

GOL

Primary Citation

Clinical and molecular characterization of a novel pathogenic AIFM1 E336K mutation connecting mitochondrial dysfunction and neurodegeneration.

Ferrer, M, Pedron, M, Soriano, O, Martinez-Julvez, M, Marin-Baquero, M, Garcia-Villanueva, R, Velazquez-Campoy, A, Marco-Brualla, J, Ripolles-Yuba, C, Fernandez-Silva, P, Medina, M, Miramar, M.D, Bestue, M, Moreno-Loshuertos, R, Ferreira, P.Show

Cell Commun Signal ? ? ? (2026)

PMID: 41957773 DOI: 10.1186/s12964-026-02862-8

Primary Citation of related structures

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