ISDA: 9SXF

Deposition Date 2025-10-09

Release Date 2026-10-21

Last Version Date 2026-10-21

Entry Detail

PDB ID:

9SXF

Keywords:

TRANSFERASE

Title:

c-KIT kinase domain in complex with (R)-Pyrrolidine derivative of AZD7762

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.19

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mast/stem cell growth factor
Gene (Uniprot):KIT
Mutagens:expression tag GSM; internal deletion from 688-765,which has been replaced with the following sequence "EFVPYKVAPEDLYKDFLT"; engineered mutations I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D
Chain IDs:A
Chain Length:327
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P10721 EC:2.7.10.1

Ligand Molecules

A1JRG

Primary Citation

Compound-screen identifies first-in-class inhibitor of multi-drug resistant KIT and PDGFRA AP/AL mutations

Muehlenberg, T, Teuber, A, Kleinboelting, S.B, Mueller, M.P, Rauh, D.Show

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Primary Citation of related structures

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