9SUY image
Deposition Date 2025-09-30
Release Date 2026-03-18
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9SUY
Keywords:
TRANSFERASE
Title:
TPX2 7-20 fused to Aurora-A residues 116-389, covalently modified on Cys290 by F104 (7-((perfluorophenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.27 Å
R-Value Free:
0.25
R-Value Work:
0.20
Space Group:
P 41 21 2
9SUY validation report
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Targeting protein for Xklp2,A
Gene (Uniprot):AURKA, TPX2
Mutagens:D274N
Chain IDs:A
Chain Length:291
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9ULW0,O14965 Pfam ID:PF00069 EC:2.7.11.1
Ligand Molecules
A1JQV
ADP
GOL
MES
MG
PGE
Primary Citation
High-throughput discovery and characterisation of pentafluorobenzene sulfonamide modifiers of Aurora A kinase.
Rsc Chem Biol ? ? ? (2026)
PMID: 41847687 DOI: 10.1039/d5cb00290g
Primary Citation of related structures
9SUY
Feedback Form
Name
Email
Institute
Feedback