ISDA: 9SUV

Deposition Date 2025-09-30

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9SUV

Keywords:

TRANSFERASE

Title:

Structure of an inhibitor of Human TGF-beta Type I Receptor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.50 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TGF-beta receptor type-1
Gene (Uniprot):TGFBR1
Chain IDs:A
Chain Length:306
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P36897 Pfam ID:PF00069 EC:2.7.10.2

Ligand Molecules

A1JQO

GOL

Primary Citation

Discovery of a Novel Lung-Restricted ALK5 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis

Ronchi, P, Pizzirani, D, Pala, D, Capelli, A.M, Rescigno, D, Bertani, B, Trist, I.M.L, Milioli, M, Cesari, N, Federico, G, Pappani, A, Venturi, L, Pecorari, D, Guariento, S, Marchini, G, Stellari, F.F, Xanxo Fernandez, S, Biagetti, M, Civelli, M, Bianchi, F, Remelli, R, Barilli, A, Pompilio, D, Hole, A.J, Caria, S, Armani, E.Show

J.Med.Chem. ? ? ? (2026)

DOI: 10.1021/acs.jmedchem.5c03825

Primary Citation of related structures

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