9SQV image
Deposition Date 2025-09-23
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9SQV
Keywords:
HYDROLASE
Title:
Cryo-EM structure of the ARISCdC(E33A):K63-Ub4 complex (Composite map)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli, Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.21 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9SQV validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Lys-63-specific deubiquitinas
Gene (Uniprot):BRCC3
Chain IDs:E (auth: A), F (auth: B)
Chain Length:316
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P46736 Pfam ID:PF01398, PF18110 EC:3.4.19.-
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:BRCA1-A complex subunit Abrax
Gene (Uniprot):ABRAXAS1
Chain IDs:C, D
Chain Length:302
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q6UWZ7 Pfam ID:PF21125
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:BRISC and BRCA1-A complex mem
Gene (Uniprot):BABAM2
Chain IDs:G (auth: F), H (auth: E)
Chain Length:385
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9NXR7 Pfam ID:PF06113
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin
Gene (Uniprot):UBC
Chain IDs:A (auth: G), B (auth: H)
Chain Length:76
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P0CG48 Pfam ID:PF00240
Ligand Molecules
ZN
Primary Citation
Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex
To Be Published ? ? ? (?)
Primary Citation of related structures
9SQV
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