9SQ5 image
Deposition Date 2025-09-19
Release Date 2026-06-17
Last Version Date 2026-06-17
Entry Detail
PDB ID:
9SQ5
Keywords:
LIGASE
Title:
Cryo-EM structure of the DDB1deltaB-CRBN-Pomalidomide complex bound to IKZF1(ZF1-ZF2-Helix)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.68 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9SQ5 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:A
Chain Length:864
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q16531 Pfam ID:PF10433, PF03178
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Gene (Uniprot):CRBN
Chain IDs:B
Chain Length:466
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96SW2 Pfam ID:PF02190, PF03226
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform Ik7 of DNA-binding pr
Gene (Uniprot):IKZF1
Chain IDs:C
Chain Length:111
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13422 Pfam ID:PF00096
Ligand Molecules
Y70
ZN
Primary Citation
Cryo-EM structure of the DDB1deltaB-CRBN-Pomalidomide complex bound to IKZF1(ZF1-ZF2-Helix)
To Be Published ? ? ? (?)
Primary Citation of related structures
9SQ5
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