9SPR image
Deposition Date 2025-09-17
Release Date 2026-04-22
Last Version Date 2026-09-30
Entry Detail
PDB ID:
9SPR
Keywords:
TRANSCRIPTION
Title:
p53 cancer mutant R282W in complex with DARPin C10
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.66 Å
R-Value Free:
0.20
R-Value Work:
0.15
R-Value Observed:
0.15
Space Group:
P 1 21 1
9SPR validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cellular tumor antigen p53
Gene (Uniprot):TP53
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P04637 Pfam ID:PF00870
Polymer Type:polypeptide(L)
Molecule:DARPin C10
Chain IDs:B (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
EDO
ZN
Primary Citation
DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants.
Proc.Natl.Acad.Sci.USA 123 e2531747123 e2531747123 (2026)
PMID: 42048463 DOI: 10.1073/pnas.2531747123
Primary Citation of related structures
9SPR
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