9SOS image
Deposition Date 2025-09-15
Release Date 2025-09-24
Last Version Date 2026-04-15
Entry Detail
PDB ID:
9SOS
Keywords:
HYDROLASE
Title:
Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.00 Å
R-Value Free:
0.25
R-Value Work:
0.19
Space Group:
P 2 21 21
9SOS validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Metalloproteinase inhibitor 1
Gene (Uniprot):TIMP1
Chain IDs:A
Chain Length:184
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P01033 Pfam ID:PF00965 EC:3.4.24.22
Primary Citation
The human TIMP-1 unbound structure provides a platform for fragment screening.
Acta Crystallogr D Struct Biol 82 330 335 (2026)
PMID: 41834537 DOI: 10.1107/S2059798326001749
Primary Citation of related structures
9SOS
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