ISDA: 9SLX

Deposition Date 2025-09-05

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9SLX

Keywords:

TRANSFERASE

Title:

holo human GSTA1 in complex with dendrogenin A (bilary salt analogue, 3beta,5alpha-dihydroxy-6beta-[2-(1H-imidazol-4-yl)-ethylamino]-cholan-24-oic acid)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.65 Å

R-Value Free:

0.20

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glutathione S-transferase A1
Gene (Uniprot):GSTA1
Chain IDs:A, B
Chain Length:222
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P08263 Pfam ID:PF02798, PF00043 EC:2.5.1.18

Ligand Molecules

A1JOL

Primary Citation

The tumor-suppressor cholesterol metabolite dendrogenin A is produced by glutathione transferase A1-1

Ayadi, S, de Medina, P, Lacroix-Triki, M, Bunay, J, Voisin, M, Pucheu, L, Sjodin, B, Gadaleta, E, Chelala, C, Kim, H.Y.H, Franchet, C, Allal, B, Filleron, T, le Faouder, P, Mourey, L, Vija, L, Porter, N.A, Mannervik, B, Nahoum, V, Maveyraud, L, Silvente-Poirot, S, Poirot, M.Show

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Primary Citation of related structures

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