ISDA: 9SIS

Deposition Date 2025-08-29

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9SIS

Keywords:

CONTRACTILE PROTEIN

Title:

THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2 R457C mutant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.70 Å

R-Value Free:

0.29

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

P 2 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha-actinin-2
Gene (Uniprot):ACTN2
Mutagens:R457C
Chain IDs:A
Chain Length:861
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P35609 Pfam ID:PF00307, PF00435, PF08726

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
MLZ	A	LYS	modified residue

Ligand Molecules

Primary Citation

Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy

Noureddine, M, Mikolajek, H, Cowieson, N, Pinotsis, N, Robinson, P, Slater, A, Redwood, C, Loughna, S, Denning, C, Mohammed, F, Gehmlich, K.Show

Nat Commun 17 6127 ? (2026)

DOI: 10.1038/s41467-026-75392-z

Primary Citation of related structures

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