9SI8 image
Deposition Date 2025-08-28
Release Date 2026-07-29
Last Version Date 2026-07-29
Entry Detail
PDB ID:
9SI8
Keywords:
LYASE
Title:
Structure of trans-basal conformer of human CBS trapped in PLP-aminoacrylate intermediate state (CBS PLP-AA)- by Helical processing.
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.47 Å
Aggregation State:
FILAMENT
Reconstruction Method:
HELICAL
9SI8 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cystathionine beta-synthase
Gene (Uniprot):CBS
Chain IDs:A (auth: F), B (auth: E), C (auth: D), D (auth: C), E (auth: B), F (auth: A)
Chain Length:510
Number of Molecules:6
Biological Source:Homo sapiens
UniProt ID:P35520 Pfam ID:PF00291, PF00571 EC:4.2.1.22
Ligand Molecules
HEM
P1T
Primary Citation
Structural basis for a filamentous morpheein model of human cystathionine beta-synthase
Nat Commun ? ? ? (2026)
DOI: 10.1038/s41467-026-73198-7
Primary Citation of related structures
9SI8
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