ISDA: 9SCN

Deposition Date 2025-08-11

Release Date 2026-06-10

Last Version Date 2026-06-10

Entry Detail

PDB ID:

9SCN

Keywords:

HYDROLASE

Title:

Crystal structure of Tc AChE with reactivator JDS364 Monoclinic

Biological Source:

Source Organism(s):

Tetronarce californica (Taxon ID: 7787)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.40 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Acetylcholinesterase
Gene (Uniprot):ache
Chain IDs:A, B, C, D
Chain Length:532
Number of Molecules:4
Biological Source:Tetronarce californica

UniProt ID:P04058 EC:3.1.1.7

Ligand Molecules

A1JM9

NAG

Primary Citation

Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase

De Sousa, J, Calas, A.G, De La Mora, E, Landry, C, Hanak, A.S, Maryan-Instone, A, Gastellier, A.J, Coisne, C, Courageux, C, Hachani, J, Gosselet, F, Dehouck, M.P, Rousseau, C, Timperley, C.M, Weik, M, Nachon, F, Brown, R.C, Baati, R, Dias, J.Show

Eur.J.Med.Chem. 316 119023 ? (2026)

DOI: 10.1016/j.ejmech.2026.119023

Primary Citation of related structures

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