9S83 image
Deposition Date 2025-08-05
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9S83
Keywords:
DE NOVO PROTEIN
Title:
Crystal structure of de novo designed binder JUBO4 and the LEDGF PWWP domain
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.10 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 31 2 1
9S83 validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:JUBO4
Chain IDs:A
Chain Length:74
Number of Molecules:1
Biological Source:synthetic construct
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:PC4 and SFRS1-interacting pro
Gene (Uniprot):PSIP1
Chain IDs:B
Chain Length:91
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O75475 Pfam ID:PF00855
Ligand Molecules
EDO
Primary Citation
De novo design of proteinaceous binders targeting the LEDGF PWWP domain.
Protein Sci. 35 e70726 e70726 (2026)
PMID: 42489162 DOI: 10.1002/pro.70726
Primary Citation of related structures
9S83
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