ISDA: 9S81

Deposition Date 2025-08-05

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9S81

Keywords:

GENE REGULATION

Title:

Crystal structure of the LEDGF PWWP domain

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.63 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:PC4 and SFRS1-interacting pro
Gene (Uniprot):PSIP1
Chain IDs:A (auth: B), B (auth: A), C
Chain Length:91
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:O75475 Pfam ID:PF00855

Ligand Molecules

CXS

Primary Citation

De novo design of proteinaceous binders targeting the LEDGF PWWP domain.

Vantieghem, T, Delepine, J, Noppen, S, Beelen, S, Drexler, M, Holkova, J, Houser, J, Veverka, V, Schols, D, Strelkov, S.V.Show

Protein Sci. 35 e70726 e70726 (2026)

PMID: 42489162 DOI: 10.1002/pro.70726

Primary Citation of related structures

Feedback Form