9S3R image
Deposition Date 2025-07-25
Release Date 2026-05-20
Last Version Date 2026-05-20
Entry Detail
PDB ID:
9S3R
Keywords:
TRANSCRIPTION
Title:
Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni, Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9S3R validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:A
Chain Length:1140
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q16531 Pfam ID:PF10433, PF23726, PF03178
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DDB1- and CUL4-associated fac
Gene (Uniprot):DCAF16
Chain IDs:B
Chain Length:218
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NXF7 Pfam ID:PF15349
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Probable global transcription
Gene (Uniprot):SMARCA2
Chain IDs:C
Chain Length:123
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P51531 Pfam ID:PF00439 EC:3.6.4.-
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DET1- and DDB1-associated pro
Gene (Uniprot):DDA1
Chain IDs:D
Chain Length:102
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BW61 Pfam ID:PF10172
Ligand Molecules
A1JLV
ZN
Primary Citation
Dual E3 ligase recruitment by monovalent degraders enables redundant and tunable degradation of SMARCA2/4.
To Be Published ? ? ? (?)
Primary Citation of related structures
9S3R
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