9S2M image
Deposition Date 2025-07-21
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9S2M
Keywords:
PEPTIDE BINDING PROTEIN
Title:
Ternary structure of 14-3-3s, CRAF S257L NS mutant phosphopeptide (pS259), and compound 23 (1083848)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.00 Å
R-Value Free:
0.22
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 2 21 21
9S2M validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:14-3-3 protein sigma
Gene (Uniprot):SFN
Chain IDs:A (auth: B), C (auth: K)
Chain Length:236
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P31947 Pfam ID:PF00244
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RAF proto-oncogene serine/thr
Gene (Uniprot):RAF1
Mutagens:S257L
Chain IDs:B (auth: H), D (auth: S)
Chain Length:11
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P04049 EC:2.7.10.2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP B SER modified residue
Ligand Molecules
CL
MG
WQI
Primary Citation
Restoring the 14-3-3/CRAF regulatory interaction in Noonan Syndrome using molecular glues
To Be Published ? ? ? (?)
Primary Citation of related structures
9S2M
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