ISDA: 9S1F

Deposition Date 2025-07-18

Release Date 2026-02-18

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9S1F

Keywords:

ANTIVIRAL PROTEIN

Title:

Cryo-EM structure of activated retron Eco2 (Ec67)

Biological Source:

Source Organism(s):

Escherichia coli NCTC 86 (Taxon ID: 662541)

Expression System(s):

Escherichia coli dh5[alpha]

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Retron Ec67 protein
Gene (Uniprot):ret
Chain IDs:D (auth: B), G (auth: A), I (auth: C)
Chain Length:596
Number of Molecules:3
Biological Source:Escherichia coli NCTC 86

UniProt ID:P21325

Polymer Type:polyribonucleotide
Molecule:RNA (132-MER)
Chain IDs:A (auth: D), B (auth: E), C (auth: F)
Chain Length:132
Number of Molecules:3
Biological Source:Escherichia coli NCTC 86

Polymer Type:polydeoxyribonucleotide
Molecule:msDNA (67-MER)
Chain IDs:E (auth: G), F (auth: I), H
Chain Length:67
Number of Molecules:3
Biological Source:Escherichia coli NCTC 86

Ligand Molecules

Primary Citation

Structure and mechanism of antiphage retron Eco2.

Jasnauskaite, M, Juozapaitis, J, Liegute, T, Grigaitis, R, Skorupskaite, A, Steinchen, W, Miksys, A, Truncaite, L, Kazlauskaite, K, Torres Jimenez, M.F, Khochare, S, Dudas, G, Bange, G, Malinauskaite, L, Songailiene, I, Pausch, P.Show

Nat.Struct.Mol.Biol. 33 330 340 (2026)

PMID: 41709047 DOI: 10.1038/s41594-026-01754-2

Primary Citation of related structures

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