ISDA: 9S0V

Deposition Date 2025-07-17

Release Date 2025-09-17

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9S0V

Keywords:

HYDROLASE

Title:

The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (hTNAP) in complex with phosphate

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.35 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

C 2 2 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alkaline phosphatase, tissue-
Gene (Uniprot):ALPL
Chain IDs:A, B, C, D, E
Chain Length:0
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:P05186 Pfam ID:PF00245 EC:3.1.3.1

Ligand Molecules

NAG

PO4

Primary Citation

TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream.

Drevet Mulard, E, Imam, I, Coureux, P.D, Briolay, A, Bessueille, L, Tarby, A, Balayssac, S, Narisawa, S, Lecornu, F, Gilard, V, Violot, S, Millan, J.L, Rautureau, G.J.P, Ballut, L, Magne, D.Show

Commun Biol 8 1501 1501 (2025)

PMID: 41145834 DOI: 10.1038/s42003-025-08901-3

Primary Citation of related structures

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