ISDA: 9S0R

Deposition Date 2025-07-16

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9S0R

Keywords:

TRANSPORT PROTEIN

Title:

Cryo-EM structure of human NHE6 in C1 symmetry

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sodium/hydrogen exchanger 6
Gene (Uniprot):SLC9A6
Chain IDs:A, B
Chain Length:701
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q92581 Pfam ID:PF00999

Ligand Molecules

Primary Citation

Integrative structural analysis of the human endosomal Na/H exchanger NHE6 reveals lipid-modulated gating of the ion-binding site

Feilen, L.P, Sach, L, Tranchant, E.E, Lalic, M.R, Havelund, J.F, Brauer, C.M, Ginsthofer, M, Ostendorf, J, Ma, L, Morrow, E.M, Faergeman, N.J, Pedersen, S.F, Kragelund, B.B, Autzen, H.E.Show

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Primary Citation of related structures

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