ISDA: 9RZB

Deposition Date 2025-07-15

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9RZB

Keywords:

HYDROLASE

Title:

Crystal structure of SARS-CoV-2 NSP3 Macrodomain in complex with SRI1.112 at room temperature

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.53 Å

R-Value Free:

0.17

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Papain-like protease nsp3
Gene (Uniprot):rep
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF01661 EC:2.7.7.48

Ligand Molecules

A1JKG

Primary Citation

Group deposition of SARS-CoV-2 NSP3 Macrodomain in complex with AI-designed inhibitors from the CIB-CSIC at room temperature

Lambert, M.C, Thompson, A.J, Sanchez-Weatherby, J, Sandy, J, Mikolajek, H, Hough, M.A, Wang, S, Fairhead, M, Williams, E.P, Martinez, A, Gil, C, Ramos, S, Aledavood, E, Born, J, Walsh, M.Show

to be published ? ? ? (?)

Primary Citation of related structures

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