ISDA: 9RYL

Deposition Date 2025-07-15

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9RYL

Keywords:

TRANSFERASE

Title:

METTL1 bound to the SAM competitive small molecule inhibitor STM9005

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.44 Å

R-Value Free:

0.19

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 61

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:tRNA (guanine-N(7)-)-methyltr
Chain IDs:A
Chain Length:235
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1JKJ

EDO

SO4

Primary Citation

Pharmacological inhibition of METTL1 as a novel anti-cancer strategy

Yankova, E, Sapetschnig, A, Thomas, B, Evans, S, Eleftheriou, M, Fischl, H, Bucknell, S, Hutchin, A, Livi, C, Azevedo, A, Webster, N, Rogan, J, Russell, J, Andrews, B, Weisser, H, Baxter, J, Mantica, G, Lopez-Leon, D, Tandon, V, Fosbeary, R, Gozdecka, M, Stamou, E, Vick, B, Sawyer, S, Usluer, S, Joseph, N, Bejar, M.T, Rad, R, Jeremias, I, Laurenti, E, Li, J, Alcolea, M.P, Adams, D.J, Vassiliou, G.S, Khaled, W.T, Rausch, O, Tzelepis, K.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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