ISDA: 9RWI

Deposition Date 2025-07-09

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9RWI

Keywords:

IMMUNE SYSTEM

Title:

crystal structure of a human leukocyte antigen-A (HLA-G) blocking antibody

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Oryctolagus cuniculus (Taxon ID: 9986)

Expression System(s):

Homo sapiens, Cricetulus griseus

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.45 Å

R-Value Free:

0.29

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

P 42 2 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:HLA class I histocompatibilit
Gene (Uniprot):HLA-G
Chain IDs:B (auth: A)
Chain Length:275
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P17693 Pfam ID:PF00129, PF07654

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:C (auth: B)
Chain Length:99
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61769 Pfam ID:PF07654

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fab heavy chain
Chain IDs:D (auth: H)
Chain Length:212
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fab light chain
Chain IDs:E (auth: L)
Chain Length:213
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2AX
Gene (Uniprot):H2AX
Chain IDs:A (auth: P)
Chain Length:8
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P16104

Ligand Molecules

Primary Citation

Preclinical characterisation and activity of a human leukocyte antigen-A (HLA-G) blocking antibody with enhanced Fc receptor-mediated effector function

O Dowd, V, McElhone, R, Thompson, C, Le Friec, G, Berteau, C, Colley, T, Dedi, N, Prosser, C, Leysen, S, Ahdash, Z, White, A.Show

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Primary Citation of related structures

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