ISDA: 9RUN

Deposition Date 2025-07-04

Release Date 2026-07-15

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9RUN

Keywords:

OXIDOREDUCTASE

Title:

Tetrapodal ancestor of L-amino acid oxidase: W377I mutant

Biological Source:

Source Organism(s):

Tetrapoda (Taxon ID: 32523)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.26 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Tetrapodal ancestor of L-amin
Chain IDs:A, B
Chain Length:488
Number of Molecules:2
Biological Source:Tetrapoda

Ligand Molecules

FAD

GOL

NO3

PEG

Primary Citation

Evolution of human IL4I1 preference for aromatic amino acids from a broad-specificity L-amino acid oxidase ancestor.

Massari, M, Caroli, J, Malatesta, M, Marchese, S, Sente, F, Pizzorni, L, Mattevi, A.Show

Proc.Natl.Acad.Sci.USA 123 e2608436123 e2608436123 (2026)

PMID: 42585003 DOI: 10.1073/pnas.2608436123

Primary Citation of related structures

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