ISDA: 9RTR

Deposition Date 2025-07-03

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9RTR

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of BRAF:MEK1 complex with asymmetric dimer interface bound to AMPPNP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.60 Å

R-Value Free:

0.26

R-Value Work:

0.20

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):BRAF
Chain IDs:B (auth: C), D (auth: B)
Chain Length:282
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P15056 Pfam ID:PF07714 EC:2.7.10.2

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dual specificity mitogen-acti
Gene (Uniprot):MAP2K1
Chain IDs:A (auth: D), C (auth: A)
Chain Length:358
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q02750 Pfam ID:PF00069 EC:2.7.12.2

Ligand Molecules