ISDA: 9RRQ

Deposition Date 2025-06-27

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9RRQ

Keywords:

MEMBRANE PROTEIN

Title:

Human TRPC5 in complex with (-) englerin A, partial occupancy (2EA:2LIP stoichiometry) state 1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Short transient receptor pote
Gene (Uniprot):TRPC5
Chain IDs:A, B (auth: C), C (auth: B), D
Chain Length:765
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q9UL62 Pfam ID:PF12796, PF00023, PF08344, PF00520

Ligand Molecules

A1L55

PTY

Y01

YZY

Primary Citation

(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation.

Porav, S.A, Ptakova, A, Bauer, C.C, Hammond, K.L.R, Beech, D.J, Vlachova, V, Muench, S.P, Bon, R.S.Show

Nat Commun ? ? ? (2026)

PMID: 42056091 DOI: 10.1038/s41467-026-71840-y

Primary Citation of related structures

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