ISDA: 9RPQ

Deposition Date 2025-06-25

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9RPQ

Keywords:

DNA BINDING PROTEIN

Title:

MeCP2 MBD domain (P152R) in complex with hydroxymethylated CA repeat DNA

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.92 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Methyl-CpG-binding protein 2
Gene (Uniprot):MECP2
Chain IDs:A
Chain Length:99
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P51608 Pfam ID:PF01429

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*TP*CP*TP*GP*CP*AP*
Chain IDs:B
Chain Length:20
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*AP*TP*AP*TP*AP*AP*
Chain IDs:C
Chain Length:20
Number of Molecules:1
Biological Source:Homo sapiens

Primary Citation

MeCP2 dysfunction in Rett syndrome mutations is triggered by specificity loss of DNA recognition

Guggenbuhl, S, Mohideen Patel, A.K, Hazemann, I, Klaholz, B.P.Show

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Primary Citation of related structures

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