ISDA: 9RP6

Deposition Date 2025-06-23

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9RP6

Keywords:

CHAPERONE

Title:

Crystal structure of covalent PDE6delta adduct modified by compound 13b

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.22

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 32 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Retinal rod rhodopsin-sensiti
Gene (Uniprot):PDE6D
Chain IDs:A
Chain Length:156
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O43924

Ligand Molecules

A1JIC

GOL

Primary Citation

Targeting a Glutamic Acid in PDE delta with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling.

Zhang, R, Huetzen, M.A, Binici, A, Martin-Gago, P, Gasper, R, Rudashevskaya, E, Liu, J, Nagaraju, C, Reckzeh, E.S, Stuedle, A.S.T, Hopff, A.S, Mesaros, A, Unger, A, Thelen, M, Janning, P, Reinhardt, H.C, Ziegler, S, Jachimowicz, R.D, Waldmann, H.Show

J.Med.Chem. 69 964 981 (2026)

PMID: 41499451 DOI: 10.1021/acs.jmedchem.5c02082

Primary Citation of related structures

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