ISDA: 9RL6

Deposition Date 2025-06-16

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9RL6

Keywords:

DNA BINDING PROTEIN

Title:

Structure Guided Optimisation of Niclosamide Derivatives as Direct STAT3 Inhibitors Targeting a Novel Binding Site

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.55 Å

R-Value Free:

0.24

R-Value Work:

0.21

Space Group:

I 41

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform Stat3B of Signal tran
Gene (Uniprot):Stat3
Chain IDs:B (auth: A)
Chain Length:596
Number of Molecules:1
Biological Source:Mus musculus

UniProt ID:P42227 Pfam ID:PF01017, PF02864, PF21354, PF00017

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*TP*GP*CP*AP*TP*TP*
Chain IDs:A (auth: B)
Chain Length:18
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

VUT

Primary Citation

Structure Guided Optimisation of Niclosamide Derivatives as Direct STAT3 Inhibitors Targeting a Novel Binding Site

Quamruzzaman, M, Maneshi, P, Knight, R, Parkinson, G.N, Wells, G.Show

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Primary Citation of related structures

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