ISDA: 9RL5

Deposition Date 2025-06-16

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9RL5

Keywords:

MEMBRANE PROTEIN

Title:

a5b3 GABAAR bound to Topiramate, GABA, and Mb25 in a desensitized state in saposin nanodiscs

Biological Source:

Source Organism(s):

Aequorea victoria (Taxon ID: 6100)
Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Homo sapiens, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Green fluorescent protein,Gam
Gene (Uniprot):GABRA5
Chain IDs:A, D
Chain Length:679
Number of Molecules:2
Biological Source:Aequorea victoria, Homo sapiens

UniProt ID:P31644 Pfam ID:PF02931, PF02932

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Gamma-aminobutyric acid recep
Gene (Uniprot):GABRB3, GFP
Chain IDs:B, C, E
Chain Length:623
Number of Molecules:3
Biological Source:Homo sapiens, Aequorea victoria

UniProt ID:P28472,P42212 Pfam ID:PF02931, PF02932

Polymer Type:polypeptide(L)
Molecule:Megabody 25
Chain IDs:F (auth: P)
Chain Length:541
Number of Molecules:1
Biological Source:Escherichia coli

Ligand Molecules