9RKZ image
Deposition Date 2025-06-15
Release Date 2026-06-24
Last Version Date 2026-06-24
Entry Detail
PDB ID:
9RKZ
Keywords:
HYDROLASE
Title:
CryoEM structure of human 20S proteasome in complex with proteasome inhibitor CP-17
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens environmental sample
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.95 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9RKZ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA6
Chain IDs:A, O
Chain Length:246
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P60900 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA2
Chain IDs:B, P
Chain Length:234
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25787 Pfam ID:PF10584, PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA4
Chain IDs:C, Q
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25789 Pfam ID:PF10584, PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA7
Chain IDs:K (auth: D), Y (auth: Z)
Chain Length:248
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:O14818 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA5
Chain IDs:D (auth: E), R
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28066 Pfam ID:PF10584, PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA1
Chain IDs:E (auth: F), S
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25786 Pfam ID:PF10584, PF00227
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA3
Chain IDs:F (auth: G), T
Chain Length:255
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P25788 Pfam ID:PF10584, PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB6
Chain IDs:L (auth: H), Z (auth: a)
Chain Length:205
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28072 Pfam ID:PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB7
Chain IDs:M (auth: I), AA (auth: b)
Chain Length:234
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q99436 Pfam ID:PF00227, PF12465 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB3
Chain IDs:G (auth: J), U (auth: V)
Chain Length:204
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49720 Pfam ID:PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB2
Chain IDs:H (auth: K), V (auth: W)
Chain Length:201
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49721 Pfam ID:PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB5
Chain IDs:N (auth: L), BA (auth: c)
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28074 Pfam ID:PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB1
Chain IDs:I (auth: M), W (auth: X)
Chain Length:213
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P20618 Pfam ID:PF00227 EC:3.4.25.1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB4
Chain IDs:J (auth: N), X (auth: Y)
Chain Length:219
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P28070 Pfam ID:PF00227 EC:3.4.25.1
Ligand Molecules
A1JHK
Primary Citation
CryoEM structure of human 20S proteasome in complex with proteasome inhibitor CP-17
To Be Published ? ? ? (?)
Primary Citation of related structures
9RKZ
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