ISDA: 9RKW

Deposition Date 2025-06-15

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9RKW

Keywords:

MEMBRANE PROTEIN

Title:

Insulin receptor ectodomain in complex with s661 insulin mimetic

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

8.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Insulin receptor
Gene (Uniprot):INSR
Chain IDs:A, B (auth: C)
Chain Length:719
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P06213 Pfam ID:PF01030, PF00757, PF00041, PF17870 EC:2.7.10.1

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Insulin receptor
Gene (Uniprot):INSR
Chain IDs:C (auth: D)
Chain Length:162
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P06213 Pfam ID:PF01030, PF00757, PF00041, PF17870 EC:2.7.10.1

Protein Blast

Polymer Type:polypeptide(L)
Molecule:s661 peptide
Chain IDs:D (auth: Z)
Chain Length:43
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state

Polak, M, Pinkas, M, Hernandez, M.S.G, Fabre, B, Lubos, M, Zakova, L, Grzybek, M, Schaefer, I.B, Coskun, U, Jiracek, J, Novacek, J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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