ISDA: 9RJC

Deposition Date 2025-06-12

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9RJC

Keywords:

MEMBRANE PROTEIN

Title:

Apo Structure of the Human Signal Peptidase

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Signal peptidase complex cata
Gene (Uniprot):SEC11A
Chain IDs:A
Chain Length:177
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P67812 Pfam ID:PF00717 EC:3.4.21.89

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Signal peptidase complex subu
Gene (Uniprot):SPCS1
Chain IDs:B
Chain Length:64
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y6A9 Pfam ID:PF06645

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Signal peptidase complex subu
Gene (Uniprot):SPCS2
Chain IDs:C
Chain Length:177
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15005 Pfam ID:PF06703 EC:3.4.21.89

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Signal peptidase complex subu
Gene (Uniprot):SPCS3
Chain IDs:D
Chain Length:174
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61009 Pfam ID:PF04573

Ligand Molecules

Primary Citation

Structure of the human signal peptidase complex with a signal peptide

Liaci, A.M, Vismpas, D, Kjolbye, L.R, Skalidis, I, Periera, G.P, Koh, A.F, Grollers-Mulderij, M, Kotecha, A, Souza, P.C.T, Forster, F.G.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-73423-3

Primary Citation of related structures

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