ISDA: 9RHO

Deposition Date 2025-06-09

Release Date 2026-06-24

Last Version Date 2026-07-01

Entry Detail

PDB ID:

9RHO

Keywords:

VIRUS

Title:

Structure of SARS-coV-2 NSP3 macrodomain in complex with ligand

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.60 Å

R-Value Free:

0.14

R-Value Work:

0.12

R-Value Observed:

0.12

Space Group:

P 31

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Papain-like protease nsp3
Chain IDs:A, B
Chain Length:169
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC1 Pfam ID:PF01661 EC:3.4.19.12,3.4.22.-

Ligand Molecules

A1JGA

Primary Citation

Targeting a viral macrodomain: Design, structure-based optimization and antiviral evaluation of potent inhibitors for Mac1 of SARS-CoV-2

Fliegert, R, Sandmann, M, Tajdar, S, Sander, S, Carrillo, D, Ganter, B, Ocenas, M, Etzold, S, Pekarek, N, Berger, J, Meister, T.L, Watt, J, Baszczynski, O, Potter, B, Alai, M.G, Henning, T, Susanne, P, Meier, C.Show

To Be Published ? ? ? (2026)

Primary Citation of related structures

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