9RGU image
Deposition Date 2025-06-07
Release Date 2026-05-13
Last Version Date 2026-05-13
Entry Detail
PDB ID:
9RGU
Keywords:
LYASE
Title:
Crystal Structure of Rattus norvegicus Enoyl-CoA Hydratase in complex with 3S hydroxyhexanoyl-PAN and 3',5', diphosphate adenosine
Biological Source:
Source Organism(s):
Rattus norvegicus (Taxon ID: 10116)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.70 Å
R-Value Free:
0.24
R-Value Work:
0.21
Space Group:
P 21 21 21
9RGU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Enoyl-CoA hydratase, mitochon
Gene (Uniprot):Echs1
Chain IDs:A, F
Chain Length:290
Number of Molecules:2
Biological Source:Rattus norvegicus
UniProt ID:P14604 Pfam ID:PF00378 EC:4.2.1.17
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Enoyl-CoA hydratase, mitochon
Gene (Uniprot):Echs1
Chain IDs:B, C
Chain Length:290
Number of Molecules:2
Biological Source:Rattus norvegicus
UniProt ID:P14604 Pfam ID:PF00378 EC:4.2.1.17
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Enoyl-CoA hydratase, mitochon
Gene (Uniprot):Echs1
Chain IDs:D
Chain Length:290
Number of Molecules:1
Biological Source:Rattus norvegicus
UniProt ID:P14604 Pfam ID:PF00378 EC:4.2.1.17
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Enoyl-CoA hydratase, mitochon
Gene (Uniprot):Echs1
Chain IDs:E
Chain Length:290
Number of Molecules:1
Biological Source:Rattus norvegicus
UniProt ID:P14604 Pfam ID:PF00378 EC:4.2.1.17
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CSD D CYS modified residue
CSO A CYS modified residue
Ligand Molecules
A1JF6
A3P
COA
Primary Citation
Enantioselective Hydration of Non-CoA Enoyl-Thioesters by Enoyl-CoA Hydratase (ECH): Activation of the Active Site Oxyanion Hole with 3',5'-Adenosine-Diphosphate Enables Competent Catalysis.
Jacs Au 6 2464 2472 (2026)
PMID: 42063829 DOI: 10.1021/jacsau.6c00054
Primary Citation of related structures
9RGU
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