ISDA: 9RGK

Deposition Date 2025-06-06

Release Date 2026-03-18

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9RGK

Keywords:

TRANSPORT PROTEIN

Title:

Human Transthyretin I107V Mutant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.70 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transthyretin
Gene (Uniprot):TTR
Mutagens:I107V
Chain IDs:A, B
Chain Length:129
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P02766 Pfam ID:PF00576

Ligand Molecules

GOL

Primary Citation

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation.

Body, I.L, Fazekas, Z, Wagner, N, Kiss-Szeman, A.J, Harmat, V, Pozsonyi, Z, Menyhard, D.K, Perczel, A.Show

Febs J. ? ? ? (2026)

PMID: 41830400 DOI: 10.1111/febs.70485

Primary Citation of related structures

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