ISDA: 9RFN

Deposition Date 2025-06-04

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9RFN

Keywords:

TRANSFERASE

Title:

Structure of protein kinase CK2alpha mutant E264D associated with the Okur-Chung Neurodevelopmental Syndrome

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.58 Å

R-Value Free:

0.27

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Casein kinase II subunit alph
Gene (Uniprot):CSNK2A1
Mutagens:E264D
Chain IDs:A, B
Chain Length:411
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P68400 EC:2.7.11.1

Ligand Molecules

EDO

SO4

Primary Citation

Functional characterization of 42 CK2 alpha de novo variants associated with Okur-Chung neurodevelopmental syndrome.

Gast, A, Werner, C, Niefind, K, Jose, J.Show

Febs J. ? ? ? (2026)

PMID: 41978434 DOI: 10.1111/febs.70538

Primary Citation of related structures

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