ISDA: 9RBM

Deposition Date 2025-05-27

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9RBM

Keywords:

LYASE

Title:

Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide MKV466

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Komagataella pastoris

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.95 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

H 3

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Carbonic anhydrase 9
Gene (Uniprot):CA9
Mutagens:C41S, N213Q
Chain IDs:A, B, C, D
Chain Length:256
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q16790 Pfam ID:PF00194 EC:4.2.1.1

Ligand Molecules

A1H89

Primary Citation

Achieving femtomolar affinities in structure-based drug design.

Zubriene, A, Kurtenoka, M, Paketuryte-Latve, V, Leitans, J, Manakova, E, Zvirblis, M, Kazaks, A, Eimonta, V, Tars, K, Grazulis, S, Petrauskas, V, Matuliene, J, Dudutiene, V, Shubin, K, Matulis, D.Show

Eur.Biophys.J. 55 55 62 (2026)

PMID: 41553426 DOI: 10.1007/s00249-025-01812-5

Primary Citation of related structures

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