ISDA: 9R6V

Deposition Date 2025-05-13

Release Date 2026-01-28

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9R6V

Keywords:

LIGASE

Title:

Crystal structure of the DOC domain of the E3 ligase HECTD3

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.61 Å

R-Value Free:

0.21

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase H
Gene (Uniprot):HECTD3
Chain IDs:A, B
Chain Length:143
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q5T447 Pfam ID:PF03256 EC:2.3.2.26

Ligand Molecules

Primary Citation

Structure and mechanism of the HECT ligase HECTD3.

Huber, J, Esposito, D, Maslen, S, Chambers, D.O, Skehel, J.M, Rittinger, K.Show

Nat Commun 17 ? ? (2026)

PMID: 41690955 DOI: 10.1038/s41467-026-69520-y

Primary Citation of related structures

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