ISDA: 9R6S

Deposition Date 2025-05-13

Release Date 2026-03-11

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9R6S

Keywords:

VIRAL PROTEIN

Title:

Prefusion stabilized spike glycoprotein of human coronavirus OC43.

Biological Source:

Source Organism(s):

Human coronavirus OC43 (Taxon ID: 31631)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Spike glycoprotein
Chain IDs:A, B, C
Chain Length:1297
Number of Molecules:3
Biological Source:Human coronavirus OC43

Ligand Molecules

8Z9

NAG

Primary Citation

AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design.

Melchers, J.M, Juraszek, J, Hulswit, R.J.G, van Overveld, D, Le, L, van Kuppeveld, F.J.M, Hurdiss, D.L, Bosch, B.J, Langedijk, J.P.M, Bakkers, M.J.G.Show

Plos Pathog. 22 e1013998 e1013998 (2026)

PMID: 41871159 DOI: 10.1371/journal.ppat.1013998

Primary Citation of related structures

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