ISDA: 9R16

Deposition Date 2025-04-25

Release Date 2026-01-28

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9R16

Keywords:

HYDROLASE

Title:

Structure of mutant SHP2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.63 Å

R-Value Free:

0.30

R-Value Work:

0.28

R-Value Observed:

0.28

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein phosphatase
Gene (Uniprot):PTPN11
Mutagens:Y62D
Chain IDs:A, B
Chain Length:536
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q06124 Pfam ID:PF00017, PF00102 EC:3.1.3.48

Primary Citation

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance.

Karunaraj, P, Scheele, R, Wells, M.L, Rathod, R, Abrahamson, S, Taylor, L.C, Gokulu, I.S, Chowdhury, L, Kazmi, A, Song, W, Hornbeck, P, Li, J, Glasgow, A, Vasan, N.Show

Biorxiv ? ? ? (2025)

PMID: 40667115 DOI: 10.1101/2025.06.11.659120

Primary Citation of related structures

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