ISDA: 9R0A

Deposition Date 2025-04-24

Release Date 2026-02-11

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9R0A

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of rat SLCO2A1 bound to fentiazac.

Biological Source:

Source Organism(s):

Rattus norvegicus (Taxon ID: 10116)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Solute carrier organic anion
Gene (Uniprot):Slco2a1
Chain IDs:A
Chain Length:663
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:Q00910 Pfam ID:PF03137, PF07648

Ligand Molecules

A1JBL

AV0

Primary Citation

Structural basis for prostaglandin and drug transport via SLCO2A1.

Joshi, C, Deme, J.C, Nakamura, Y, Hsu, W.T, Goult, J.D, Kato, T, Parker, J.L, Biggin, P.C, Lea, S.M, Nakanishi, T, Newstead, S.Show

Nat Commun 17 ? ? (2026)

PMID: 41862483 DOI: 10.1038/s41467-026-70227-3

Primary Citation of related structures

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