ISDA: 9QSM

Deposition Date 2025-04-05

Release Date 2026-02-18

Last Version Date 2026-02-25

Entry Detail

PDB ID:

9QSM

Keywords:

IMMUNE SYSTEM

Title:

small molecule inhibitor in complex with PD-L1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.75 Å

R-Value Free:

0.27

R-Value Work:

0.24

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Programmed cell death 1 ligan
Gene (Uniprot):CD274
Chain IDs:A, B, C, D, E, F
Chain Length:128
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:Q9NZQ7 Pfam ID:PF07686

Ligand Molecules

A1JAE

Primary Citation

N-terphenylpicolinamide derivatives designed to target PD-L1 increase activation and proliferation of T cells, and their cytotoxic properties toward cancer cells.

Muszak, D, Kocik-Krol, J, Zaber, J, Kruc, O, Palej, U, Fijolkowska, K, Maslanka, A, Magiera-Mularz, K, Plewka, J, Stec, M, Surmiak, M, Szafarz, M, Siedlar, M, Musielak, B, Kitel, R, Wyska, E, Skalniak, L, Surmiak, E.Show

Eur J Med Chem 307 118652 118652 (2026)

PMID: 41691995 DOI: 10.1016/j.ejmech.2026.118652

Primary Citation of related structures

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