ISDA: 9QS5

Deposition Date 2025-04-04

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9QS5

Keywords:

VIRAL PROTEIN

Title:

SARS-CoV-2 nsp14 with 5-(thiophen-2-ylmethylamino)-3H-1,3,4-thiadiazole-2-thione

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine-N7 methyltransferase
Gene (Uniprot):rep
Chain IDs:A, B
Chain Length:523
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF06471 EC:2.7.7.48

Ligand Molecules

A1I9Y

DMS

PO4

Primary Citation

Fragment-based screening reveals novel SARS-CoV-2 nsp14 targeting fragments.

Shi, X, Wang, Q, Dong, D, Xu, M, Al Busaidi, F, Bowler, M, Haider, S, Kozielski, F.Show

To be published ? ? ? (?)

Primary Citation of related structures

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