ISDA: 9QS1

Deposition Date 2025-04-04

Release Date 2026-04-15

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9QS1

Keywords:

OXIDOREDUCTASE

Title:

Tetrapodal ancestor of L-amino acid oxidases

Biological Source:

Source Organism(s):

Tetrapoda (Taxon ID: 32523)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tetrapodal ancestor of L-amin
Chain IDs:A
Chain Length:488
Number of Molecules:1
Biological Source:Tetrapoda

UniProt ID:A0A6P7X6N5 Pfam ID:PF01593

Ligand Molecules

FAD

NO3

Primary Citation

Evolution of human IL4I1 preference for aromatic amino acids from a broad-specificity L-amino acid oxidase ancestor.

Massari, M, Caroli, J, Malatesta, M, Marchese, S, Sente, F, Pizzorni, L, Mattevi, A.Show

Proc.Natl.Acad.Sci.USA 123 e2608436123 e2608436123 (2026)

PMID: 42585003 DOI: 10.1073/pnas.2608436123

Primary Citation of related structures

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