ISDA: 9QQ2

Deposition Date 2025-03-31

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9QQ2

Keywords:

LYASE

Title:

Crystal structure of human carbonic anhydrase VII in complex with a benzenesulfonamide derivative containing the duloxetine moiety.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.35 Å

R-Value Free:

0.18

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 21 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Carbonic anhydrase 7
Gene (Uniprot):CA7
Chain IDs:A
Chain Length:274
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43166 Pfam ID:PF00194 EC:4.2.1.1

Ligand Molecules

A1I9B

Primary Citation

Multimodal Neuropathic Pain Management: Novel Approaches Through Inhibition of the Carbonic Anhydrase Enzymes

Angeli, A, Rosi, G, Micheli, L, D'Ambrosio, K, Di Fiore, A, Ghelardini, C, Di Cesare Mannelli, L, Bartolucci, G, Carta, F, De Simone, G, Papini, A.M, Supuran, C.T.Show

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